Table 1.

Demographic and Clinical Characteristics in PUMND and PUMND+LMND Groups

Initial disease classification of patient	Gender	Age of onset (years)	First evalua- tion (age, years)	Time from onset to last EMG (months)	Final disease classification	Functional outcome
PUMND
1	M	62	62	29	PUMND	WA
2	M	44	44	50	PUMND	FA
3	M	45	47	25	PUMND	FA
4	F	33	33	72	PUMND	FA
5	M	71	72	29	PUMND	WA
6	F	74	76	17	PUMND	WC, NIV
7	F	74	76	95	PUMND	FA
8	M	34	36	28	PUMND	FA
9	F	59	62	90	PUMND	WA
10	M	62	66	51	PUMND	FA
11	F	54	58	57	PUMND	FA
12	M	54	60	76	PUMND	WA
13	F	31	39	97	PUMND	FA
14*	M	38	41	37	PUMND	WA
15*	F	43	60	198	PUMND	WA
Summary, PUMND	8 M 7 F	51.8 (range,33– 74)	55.5 (range, 33–76)	63.4 (range, 17–198)	PUMND	FA = 8† WA = 6† WC = 1† NIV = 1
PUMND +LMND
16	M	48	48	82	PUMND + LMND	WA
17	F	48	49	41	PUMND + LMND	WC (Dec)
18	F	46	49	38	PUMND + LMND	WA
19	M	62	64	86	PUMND + LMND	WA
20	M	45	48	41	PUMND + LMND	WA
21	F	58	61	43	PUMND + LMND	WA
22	F	53	61	102	PUMND + LMND	WC, NIV
23	F	55	66	64	PUMND + LMND	WC, NIV
Summary, PUMND + LMND	3 M 5 F	51.8 (range, 46–62)	55.7 (range, 48–66)	62.1 (range, 38–102)	PUMND + LMND	FA = 0† WA = 5 WC = 3 NIV = 2 Dec = 1

Dec=deceased, FA=full ambulation, LMND=lower motor neuron disease/dysfunction, NIV=non-invasive ventilation, PUMND=pure upper motor neuron disease, WA=walker, WC=wheelchair.

^*had only one EMG.

^†P = 0.02 (2 by 3 Fisher Exact Test for the full ambulation, walker, and wheelchair groups).