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. Author manuscript; available in PMC: 2013 Dec 21.
Published in final edited form as: ACS Chem Biol. 2012 Sep 26;7(12):1994–2003. doi: 10.1021/cb300385m

Figure 3.

Figure 3

Active site of activating STs. a) OLS ST PAP binding site. PAP (magenta C) and surrounding amino acids (yellow C) in an intricate hydrogen-bonding network are shown in stick form in the stereo diagram. b) Schematic of PAP binding site. c) Comparison of the active sites of CurM ST and 3-OST. Key amino acids are shown in stick form in 3-OST (1T8U) (25) (purple C) and CurM ST (yellow C). Hydrogen bonds in CurM ST and the ionic interaction from Lys133 to PAP are shown in black. Hydrogen bonds in 3-OST are shown in gray. PAPS is modeled into CurM ST from the positions of PAP and ZnCl3−.