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Schematic representation of the components involved in Sec incorporation that are central to the synthesis of selenoproteins. Elements present in the mRNA of selenoproteins are an in frame UGA codon and Sec incorporation sequence (SECIS) element, a stem loop structure located in the 3’UTR (untranslated region). SBP2 binds SECIS and recruits the Sec-specific elongation factor (EFSec) and Sec-specific tRNA (tRNASec) thus resulting in the recoding of the UGA codon and Sec incorporation.
