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. Author manuscript; available in PMC: 2013 Jun 20.
Published in final edited form as: Nature. 2012 Nov 14;492(7429):443–447. doi: 10.1038/nature11709

Figure 1. Subfertility of Tet1Gt/Gt mice is associated with oocyte loss in late embryonic stage.

Figure 1

(a) Abnormal ovaries of the Tet1Gt/Gt mice. Top panel, representative images of ovaries from 8-week-old wild-type (Wt) and Tet1 mutant (Gt/Gt) mice. Both left and right ovaries from one representative female are shown. Bottom panel, representative images of Hematoxylin and Eosin staining of adult ovary sections. Arrows indicate fully-grown oocytes.

(b) Number of fully-grown oocytes in adult ovaries. n=4 or 5. Error bars indicate SEM. **P<0.01.

(c) The average number of ovulated oocytes per female after hormonal stimulation. n=5–7. Error bars indicate SEM. *P<0.05.

(d) The relative oocyte numbers normalized to that in the wild-type (Wt) mouse. The number of oocytes in Wt mice was counted and set as 1. n=2–7. Error bars indicate SEM. *P<0.05, **P<0.01.