Table 5.
Ordinal logistic regression models of embryo quality on concentrations of follicular fluid metals (square root transformed) measured in female in vitro fertilization (IVF) patients, with generalized estimating equations used to generate robust standard errors; the Study of Metals and Assisted Reproductive Technology (SMART)
| Metals (õg/L) | n (women)/ n (embryos) | Single metal models: | Multiple metals models: | ||||
|---|---|---|---|---|---|---|---|
| OR a | 95 % CI | OR b | 95 % CI | ||||
| ECN: c | |||||||
| Mercury | 34/273 | 4.37 | 0.58 | 32.71 | 3.83 | 0.36 | 40.51 |
| Cadmium | 34/273 | 6.11 | 0.07 | 574.44 | 3.18 | 0.02 | 430.78 |
| Lead | 34/273 | 0.92 | 0.23 | 3.72 | 0.84 | 0.21 | 3.42 |
| EFS: | |||||||
| Mercury | 43/285 | 1.59 | 0.19 | 40.78 | 1.24 | 0.15 | 10.41 |
| Cadmium | 43/285 | 7.66 | 0.06 | 992.67 | 4.08 | 0.03 | 639.70 |
| Lead | 43/285 | 2.38 | 0.63 | 9.03 | 2.22 | 0.62 | 7.89 |
a Odds ratio (OR) for an embryo as a function of concentrations of a single measured metal adjusted for age, cigarette smoking and race/ethnicity; b odds ratio for an embryo as a function of concentrations of all measured metals adjusted for age, cigarette smoking and race/ethnicity; c day three embryo transfers only
CI confidence interval