Table 3.
Mean tissue concentrations of cefazolin at each sample point
| Intraosseous | Systemic | |||||
|---|---|---|---|---|---|---|
| Time (minutes; ± SD) | Mean concentration (μg/g; ± SD) | 95% CI (μg/g) | Time (minutes; ± SD) | Mean concentration (μg/g; ± SD) | 95% CI (μg/g) | |
| Sample point | ||||||
| Subcutaneous fat 1 | 1.2 | 175.3 | 102–250 | 1.3 | 7.2 | 4.2–10.3 |
| (0.6) | (110) | (0.4) | (4.3) | |||
| Subcutaneous fat 2 | 11 | 193.0 | 140–247 | 14 | 12.8 | 8.4–17.2 |
| (5.1) | (79.8) | (6.6) | (6.6) | |||
| Subcutaneous fat 3 | 30 | 206.3 | 121–292 | 35 | 11.2 | 8.4–14.0 |
| (11.1) | (127) | (12.3) | (4.1) | |||
| Subcutaneous fat 4 | 56 | 169.1 | 88–250 | 54 | 11.3 | 7.1–15.4 |
| (23.2) | (120) | (17.3) | (6.2) | |||
| Bone sample 1 | 11 | 75.4 | 26–125 | 14 | 9.2 | 7.4–10.9 |
| (5.1) | (74.2) | (6.6) | (2.6) | |||
| Bone sample 2 | 30 | 165.6 | 21–311 | 35 | 14.1 | 8.6–19.6 |
| (11.1) | (216) | (12.3) | (8.2) | |||
| Bone sample 3 | 56 | 148.8 | 79–219 | 54 | 10.8 | 7.7–13.8 |
| (23.2) | (105) | (17.3) | (4.6) | |||
Times are given as minutes postsurgical incision. Differences in mean tissue concentrations between the two groups were statistically significant (p < 0.001) for all comparison points.