Table 1.

Relevant literature

Study	Antifungal	Volume fraction	Antifungal release (percent of loaded drug)	Bioactivity	Compressive strength (MPa)
Rouse et al. [14]	Anidulafungin, voriconazole	Not reported	Reported concentration only approximately 0.6% release by 24 hours	Not tested	Not tested
Sealy et al. [15]	Flucytosine, fluconazole, micafungin, terbinafine, anidulafungin	Not reported	Flucytosine: 0.54% Fluconazole: 0.67% Micafungin: 0.04% Terbinafine: 0.07% Anidulafungin: 9.68%	Drug activity reported variable	Not tested
Kweon et al. [9]	Amphotericin B deoxycholate	< 3 vol%	1% of amphotericin B recovered by Day 30 with poragen; 0.04% without poragen	Not tested	Compressive strength decreases with poragen; compressive strength slightly increased without poragen
Grimsrud et al. [6]	Voriconazole	30 vol%	Neither percent release or concentration measured; release present after 2 weeks	Active	Not tested
Silverberg et al. [16]	Amphotericin B, fluconazole, 5-flucytosine	Not reported	Not measured	Amphotericin B, fluconazole active	Not tested