Table 1.
Range of parameters used in generating model population with random sampling of parameter space
| Parameter | Default value | Testing range |
|---|---|---|
| Rm (kΩ cm2) | 11 | 10–18 |
| Cm (μF cm−2) | 1 | 0.5–1.5 |
| Diameter (μm) | 60 | 40–80 |
 (S cm−2) |
— | 0.02–0.1 |
 (μS cm−2) |
— | 100–500 |
 (μS cm−2) |
— | 30–150 |
| V1/2 activation of A channel (mV) | −1 | −20 to 20 |
| V1/2 inactivation of A channel (mV) | −56 | −80 to −40 |
| V1/2 activation of T channel (mV) | −60 | −75 to −35 |
| V1/2 inactivation of T channel (mV) | −85 | −105 to −65 |
| V1/2 activation of h channels (mV) | −82 | −100 to −60 |
| Activation time constant of A channel (ms) | 0.032 | 0.02–0.1 |
| Inactivation time constant of A channel (ms) | 2 | 1–5 |
| Activation time constant of T channel (ms) | 1.004 | 1–5 |
| Inactivation time constant of T channel (ms) | 31.012 | 10–50 |
| Activation time constant of h channel (ms) | 46.51 | 25–75 |
| Ca2+ decay time constant (ms) | 30 | 10–90 |
For each model, each parameter (first column) was drawn independently from a uniform distribution, generated around a large neighbourhood of their default values (second column), within set bounds (third column).