Table 3.
Sensitivity analysis for IRD measurements corresponding to various active parameters related to the A-type K+ channel
| A-type K+ channel | |||
|---|---|---|---|
| Effect of increase in | Tested range | Rin | |Z|max |
| Rm (kΩ cm2) | 1–10 | Increases | Increases |
| Cm (μF cm−2) | 0.5–2 | No effect | Decreases* |
 (mS cm−2) |
0–0.5 | Decreases | Decreases |
| Membrane potential (mV) | −150 to 30 | Biphasic | Biphasic |
| V1/2 activation of A channel (mV) | −150 to 0 | Inverted bell | Inverted bell |
| V1/2 inactivation of A channel (mV) | −100 to 0 | Decreases | Decreases |
| Activation time constant of A channel (ms) | 1–30 | No effect | No effect |
| Inactivation time constant of A channel (ms) | 1–100 | No effect | No effect |
Resonance-related IRD measurements are not shown because A-type K+ channels are not resonating conductances. Associated plots may be found in Figs S6–S8.
*
A very small change.