Table 6.

Sensitivity analysis for the IRD measurements corresponding to various active parameters related to T-type Ca²⁺ channel and A-type K⁺ channel, when both these channels were coexpressed in the model

		Coexpression of T and A channels
Effect of increase in	Tested range	Rin	fR	Q	|Z|max
Rm (kΩ cm2)	1–20	Increases	Decreases	Increases	Increases
Cm (μF cm−2)	0.5–2	No effect	Decreases	Decreases	Decreases
(mS cm−2)	0–200	Decreases	Increases	Decreases	Decreases
(mS cm−2)	0–0.5	Increases	Increases	Increases	Increases
V1/2 activation of A channel (mV)	−150 to 0	Increases	Bell shaped	Increases	Increases
V1/2 inactivation of A channel (mV)	−100 to 0	Decreases	Increases	Decreases	Decreases
V1/2 activation of T channel (mV)	−150 to 0	Increases	Decreases	Decreases	Increases
V1/2 inactivation of T channel (mV)	−100 to 0	Increases	Decreases	Bell shaped	Increases
Activation time constant of A channel (ms)	0.1–2	No effect	Increases	No effect	No effect
Inactivation time constant of A channel (ms)	1–200	No effect	No effect	No effect	No effect
Activation time constant of T channel (ms)	1–30	No effect	Decreases	Decreases	Decreases
Inactivation time constant of T channel (ms)	1–100	No effect	Decreases*	Increases*	Increases
Ca2+ decay time constant (ms)	5–100	No effect	No effect	No effect	No effect

^*The model can sustain resonance only after crossing a certain threshold value of inactivation time constant of the T current. As the presence of T current did not elicit an inductive phase lead in the impedance phase profile, the sensitivity for Φ_L is not presented here. Associated plots may be found in Figs 5 and S15.