Skip to main content
. 2012 Aug 28;590(Pt 22):5629–5652. doi: 10.1113/jphysiol.2012.239418

Table 6.

Sensitivity analysis for the IRD measurements corresponding to various active parameters related to T-type Ca2+ channel and A-type K+ channel, when both these channels were coexpressed in the model

Coexpression of T and A channels

Effect of increase in Tested range Rin fR Q |Z|max
Rm (kΩ cm2) 1–20 Increases Decreases Increases Increases
Cm (μF cm−2) 0.5–2 No effect Decreases Decreases Decreases
Inline graphic (mS cm−2) 0–200 Decreases Increases Decreases Decreases
Inline graphic (mS cm−2) 0–0.5 Increases Increases Increases Increases
V1/2 activation of A channel (mV) −150 to 0 Increases Bell shaped Increases Increases
V1/2 inactivation of A channel (mV) −100 to 0 Decreases Increases Decreases Decreases
V1/2 activation of T channel (mV) −150 to 0 Increases Decreases Decreases Increases
V1/2 inactivation of T channel (mV) −100 to 0 Increases Decreases Bell shaped Increases
Activation time constant of A channel (ms) 0.1–2 No effect Increases No effect No effect
Inactivation time constant of A channel (ms) 1–200 No effect No effect No effect No effect
Activation time constant of T channel (ms) 1–30 No effect Decreases Decreases Decreases
Inactivation time constant of T channel (ms) 1–100 No effect Decreases* Increases* Increases
Ca2+ decay time constant (ms) 5–100 No effect No effect No effect No effect
*

The model can sustain resonance only after crossing a certain threshold value of inactivation time constant of the T current. As the presence of T current did not elicit an inductive phase lead in the impedance phase profile, the sensitivity for ΦL is not presented here. Associated plots may be found in Figs 5 and S15.