Figure 1. GluA1 receptors with- and without TARPs open to multiple conductance levels.

A, single-channel currents recorded from GluA1 co-expressed with a TARP (γ-2, γ-4 or γ-5, as indicated). Outside-out patches were held at −80 mV; openings in the presence of 10 mm glutamate are shown as downward deflections and are illustrated at two different time scales. B, all TARPs tested exhibited multiple single-channel conductance levels. Amplitude histograms of single-channel events from individual patches fitted with multiple Gaussian components (see Methods). The mean conductances of the displayed distributions (and their relative areas) are indicated by arrows.