Table 1.
Mean, SEM and n number values for fits to conductance histograms for homomeric GluA1 receptors with and without TARPs
| Conductance level (pS) + (percentage area of component) | |||||
|---|---|---|---|---|---|
| TARP | Single-channel conductance (pS) | 1 | 2 | 3 | 4 |
| None | 13.7 ± 0.8 | 7.6 ± 0.9 | 12.9 ± 0.3 | 24.8 ± 3.9 | — |
| n= 5 | (35 ± 5) | (73 ± 15) | (34 ± 15) | ||
| γ-2 | 27.6 ± 3.4* | 11.5 ± 1.2* | 22.3 ± 2.6*** | 38.8 ± 2.8* | — |
| n= 8 | (32 ± 8) | (38 ± 8) | (42 ± 11) | ||
| γ-4 | 26.4 ± 3.5* | 12.3 ± 1.4* | 22.9 ± 1.3*** | 42.3 ± 3.6* | 57.2 ± 5.3 |
| n= 11 | (47 ± 7) | (33 ± 7) | (37 ± 8) | (9 ± 2) | |
| γ-5 | 20.8 ± 1.1* | 9.4±0.3 | 21.7±0.7 | 38.1±2.5 | — |
| n= 6 | (32±4) | (61±3) | (20±4) | ||
In the case of single-channel conductance, n refers to the number of patches. For the statistical analysis of mean conductance (column 2), all TARPs were included. For the statistical analysis of the individual conductance levels, γ-5 was excluded (italics) because of the low number of events (<100) within several of the individual conductance components, and because of the low number of patches containing conductance levels 1 and 3 (4 in each case) compared with the other TARPs. F-tests denote results of one-way ANOVA (Welch's heteroscedastic F-test) and asterisks denote results of post hoc tests comparing GluA1 with GluA1/γ-2 and GluA1/γ-4 (Welch t tests with Holm's sequential Bonferroni correction; ***P < 0.001, *P < 0.05). F3,12.62= 9.26, F2,7.96= 5.04, F2,10.43= 34.25, F2,6.75= 5.45. P= 0.0017, P= 0.039, P= 2.61e-05, P= 0.038.