Skip to main content
. 2012 Sep 17;590(Pt 22):5749–5764. doi: 10.1113/jphysiol.2012.241299

Figure 3. Strychnine-sensitive GlyRs promote neurotransmitter release.

Figure 3

A, schematic of experimental design. Pre-incubation of strychnine and d,l-2-amino-5-phosphonopentanoic acid (d,l-APV; indicated in blue) was initiated 20 min prior to the start of whole-cell recordings and maintained for the duration of the recording, while acute drugs (strychnine, s; taurine, t; glycine, g; or d-serine, D) were applied after a 10 min baseline period and then washed out after an additional 10 min. B, averaged data of normalized miniature excitatory postsynaptic current (mEPSC) frequency demonstrates acute effects of indicated drugs as a percentage of baseline. Asterisks denote significance (P < 0.05). C, averaged normalized data demonstrate that the pharmacological manipulations did not significantly alter mEPSC amplitude. Sample sizes in B and C are given within the bars. The mEPSC frequencies and amplitudes were normalized to the averaged baseline levels before acute drug application.