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. 2012 Sep 3;590(Pt 22):5795–5808. doi: 10.1113/jphysiol.2012.238659

Figure 1. The stress hormone corticosterone inhibits the amplitude of AMPAR-EPSCs in putative DR 5-HT neurons.

Figure 1

A, a representative experiment depicting the impact of corticosterone (CORT, 300 nm) on the amplitude of evoked AMPAR-EPSCs. Inset is superimposed EPSC traces taken at time points indicated by the numbers in panel A. B, summary graph of time course and magnitude of the CORT-induced inhibition of AMPAR-EPSCs (n= 12) in putative DR 5-HT neurons. C and D depict summary graphs of the effects of CORT on the holding current and membrane resistance, respectively. Note that CORT (300 nm) had no effect on the holding current (n= 12) and membrane resistance (n= 12). Calibration bars: 50 pA, 10 ms.