Table 2.
Expression levels of genes in LV from R6/1 and WT mice
| 3 months | 7 months | |||
|---|---|---|---|---|
| WT (8) | R6/1 (8) | WT (7) | R6/1 (7) | |
| α-MHC | 1.00 ± 0.08 | 0.83 ± 0.04 | 1.00 ± 0.16 | 1.06 ± 0.15 |
| SERCA2a | 1.00 ± 0.13 | 0.88 ± 0.08 | 1.00 ± 0.20 | 1.22 ± 0.14† |
| ANP | 1.00 ± 0.16 | 0.72 ± 0.20 | 1.00 ± 0.22 | 0.53 ± 0.07 |
| β-MHC | 1.00 ± 0.22 | 0.59 ± 0.14 | 1.00 ± 0.21 | 2.13 ± 0.65† |
| β1-AR | 1.00 ± 0.08 | 0.89 ± 0.08 | 1.00 ± 0.21 | 1.19 ± 0.20 |
| CPT-1β | 1.00 ± 0.11 | 1.07 ± 0.06 | 1.00 ± 0.18 | 1.08 ± 0.14 |
| Pro-Col I | ND | ND | 1.00 ± 0.15 | 0.57 ± 0.11* |
| Pro-Col III | 1.00 ± 0.12 | 0.98 ± 0.15 | 1.00 ± 0.24 | 0.46 ± 0.09† |
| Glut 4 | 1.00 ± 0.05 | 1.12 ± 0.05 | 1.00 ± 0.14 | 1.08 ± 0.12 |
| VEGF | ND | ND | 1.00 ± 0.17 | 0.92 ± 0.08 |
| PGC-1 | 1.00 ± 0.12 | 0.72 ± 0.03* | ND | ND |
Abbreviations: ANP, atrial natriuretic peptide; AR, adrenergic receptor; CPT, carnitine palmitoyltransferase; Glut, glucose transporter; MHC, myosin heavy chain; ND, not determined; PGC-1, peroxisome proliferator activated receptor γ coactivator 1-α; Pro-Col, pro-collagen; SERCA, sarcoplasmic reticulum calcium ATPase; VEGF, vascular endothelial growth factor; WT, wild-type. Gene expression levels were normalised to 18S. *P < 0.05 vs. age-matched WT (Student's unpaired t test). †P < 0.05 vs. 3-month-old R6/1. Group size indicated in parentheses.