Skip to main content
. 2012 Dec 3;109(51):21016–21021. doi: 10.1073/pnas.1219482110

Fig. 1.

Fig. 1.

DSS-induced colitis in IRF3-deficient mice. A total of 2% DSS is administered for 6 d and replaced with water on day 7. (A) Survival of WT (n = 6), IRF3-deficient (n = 5), or IRF5-deficient mice (n = 5) monitored every 24 h. (B) Colons from WT, IRF3-deficient, and IRF5-deficient mice on day 8. (C) Quantification of the colon length described in B. *P < 0.05 compared with colon from WT mice. (D) Histological analysis of H&E-stained colon sections from WT and IRF3-deficient mice treated with 2% DSS for 8 d. (Original magnification: 200×.) (E) Body weight of WT (n = 6) or IRF3-deficient mice (n = 5) monitored every 24 h. **P < 0.01 and *P < 0.05 compared with WT mice. (F) qRT-PCR analysis of Tslp and Il33 mRNA in colons from WT or IRF3-deficient mice (n = 5) on day 8. **P < 0.01 and *P < 0.05, compared with WT mice. Statistical data are presented as mean ± SD.