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CpG methylation regulates Pcdh gene expression through alteration of CTCF binding. (A) The methylated CSE sequences as representative probes. (B) EMSA experiments with methylated (Me) and unmethylated control (UMe) CSE probes. (C) Schematic of CTCF binding at each alternate promoter region of the Pcdhα cluster. (D) Inverse relationships between Pcdh gene expression and extent of CpG methylation (β score).
