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. 2012 Dec 5;109(51):21128–21133. doi: 10.1073/pnas.1211844110

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Fig. 3. — Reduced excitability of mesolimbic dopaminergic neurons in Rasgrf2^−/− mice relies on ERK-dependent modulation of I_A currents. (A) Sample traces and pooled data of current injection evoked action potentials in mutant and WT mouse brain slices (n = 5–7). A two-way ANOVA revealed a significant effect of genotype (F_1,12 = 5.09, P < 0.05). (B) Sample traces and pooled data of action potentials obtained on current injections in slices pretreated with ERK inhibitors. A two-way ANOVA revealed a significant treatment effects of inhibitors PD098059 (F_1,17 = 6.4, P < 0.05) and SL327 (F_1,15 = 4.9, P < 0.05; n = 7–8). (C) I_A measured in WT brain slices pretreated with the ERK inhibitor or vehicle (t₁₉ = 3.1, P < 0.01; n = 7–10).