Scheme 6.
Preparation of C4-OMe analogue 50. a Conditions: (a) MeI (5.0 equiv), Ag2O (2.0 equiv), DMF, 23 °C, 87%. (b) 36 (1.0 equiv), 49 (1.5 equiv), Ru-1 (7 mol%), benzoquinone (0.2 equiv), DCE, 42 °C, 57%.
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