Table 2.

Structural brain correlates of prepulse inhibition with a stimulus onset asynchrony of 120 ms in medication-naive men with first-episode schizophrenia and healthy controls^*

Anatomic area	Lobe	Side	Controls and patients, n = 65†					Controls, n = 38‡					Patients, n = 27§
			MNI coordinates			t value	Cluster size	MNI coordinates			t value	Cluster size	MNI coordinates			t value	Cluster size
			x	y	z			x	y	z			x	y	z
Superior (7A)	Parietal	R	33	−66	58	5.8¶	589	33	−60	57	4.9	140	30	−66	60	5.6	220
	Parietal	R	9	−67	51	3.8	116
Pre-SMA	Frontal	R	4	23	61	3.9	321	4	24	64	5.11	508
rPMd	Frontal	L	−21	3	72	4.3	237	−21	3	67	3.77	110
Medial superior	Frontal	R/L	0	52	15	3.9	122

L = left; MNI = Montreal Neurological Institute; R = right; rPMd = rostral dorsal premotor cortex; SMA = supplementary motor area.

^*Statistical parametric maps were thresholded at p < 0.001 with an extent threshold, empirically determined by SPM8. Only positive correlations were found. All analyses were corrected for scanner type, age and scanner drift.

^†Extent threshold of k_E = 88 voxels.

^‡Extent threshold of k_E = 75 voxels.

^§Extent threshold of k_E = 81 voxels.

^¶p = 0.006, family-wise error–corrected.