Table 8.

Comparison of strategies to identify men at risk of having a diagnosis of different types of cancer based on the top 10% at highest risk for each cancer in the validation cohort

Top 10% of risk	Risk threshold %	True negative	False negative	False positive	True positive	Sensitivity %	Specificity, %	PPV, %	NPV, %
Lung cancer	0.67	610 755	502	66 658	1259	71.5	90.2	1.9	99.9
Colorectal cancer	0.45	610 731	526	66 718	1199	69.5	90.2	1.8	99.9
Gastro-oesophageal	0.29	610 982	275	67 018	899	76.6	90.1	1.3	100.0
Pancreatic cancer	0.10	611 136	121	67 633	284	70.1	90.0	0.4	100.0
Renal tract cancer	0.20	611 026	231	66 815	1102	82.7	90.1	1.6	100.0
Prostate cancer	1.30	610 254	1 003	66 443	1474	59.5	90.2	2.2	99.8
Blood cancer	0.27	610 800	457	67 478	439	49.0	90.1	0.6	99.9
Testicular cancer	0.02	611 183	74	67 766	151	67.1	90.0	0.2	100.0
Other cancer	0.66	611 065	192	67 846	71	27.0	90.0	0.1	100.0

NPV = negative predictive value. PPV = positive predictive value.