Table 3.
Correlation coefficients for men’s reproductive hormones and creatinine-adjusted di(2-ethylhexyl) phthalate (DEHP) metabolite concentrations (univariate analysis; n = 425)
| FSH |
LH |
T |
Inhibin Ba |
E2b |
SHBG |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R | 95% CI | R | 95% CI | R | 95% CI | R | 95% CI | R | 95% CI | R | 95% CI | |
| MEHP | 0.04 | (−0.06, 0.14) | −0.03 | (−0.13, 0.07) | −0.05 | (−0.15, 0.05) | −0.05 | (−0.15, 0.05) | −0.09 | (−0.19, 0.01) | 0.14 | (0.05, 0.24)d |
| MEHHP | 0.02 | (−0.08, 0.12) | −0.04 | (−0.14, 0.06) | −0.09 | (−0.19, 0.01) | −0.03 | (−0.13, 0.07) | −0.04 | (−0.14, 0.06) | 0.03 | (−0.07, 0.13) |
| MEOHP | 0.02 | (−0.08, 0.12) | −0.05 | (−0.15, 0.05) | −0.10 | (−0.20, −0.001)c | −0.04 | (−0.14, 0.06) | −0.05 | (−0.15, 0.05) | 0.04 | (−0.06, 0.14) |
| MECPP | 0.02 | (−0.08, 0.12) | −0.06 | (−0.16, 0.04) | −0.10 | (−0.20, −0.001)c | −0.04 | (−0.14, 0.06) | −0.03 | (−0.13, 0.07) | 0.01 | (−0.09, 0.11) |
| ∑DEHP | 0.03 | (−0.07, 0.13) | −0.05 | (−0.15, 0.05) | −0.09 | (−0.19, 0.01) | −0.04 | (−0.14, 0.06) | −0.04 | (−0.14, 0.06) | 0.04 | (−0.06, 0.14) |
| FAI |
FT |
FAI/LH ratio |
FT/LH ratio |
E2/T ratiob |
T/LH ratio |
|||||||
| R | 95% CI | R | 95% CI | R | 95% CI | R | 95% CI | R | 95% CI | R | 95% CI | |
| MEHP | −0.23 | (−0.32, −0.14)d | −0.15 | (−0.25, −0.06)d | −0.13 | (−0.23, −0.04)d | −0.08 | (−0.18, 0.02) | −0.04 | (−0.14, 0.06) | −0.02 | (−0.12, 0.08) |
| MEHHP | −0.14 | (−0.24, −0.05)d | −0.13 | (−0.23, −0.04)d | −0.06 | (−0.16, 0.04) | −0.06 | (−0.16, 0.04) | 0.02 | (−0.08, 0.12) | − 0.04 | (−0.14, 0.06) |
| MEOHP | −0.15 | (−0.25, −0.06)d | −0.14 | (−0.24, −0.05)d | −0.06 | (−0.16, 0.04) | −0.06 | (−0.16, 0.04) | 0.02 | (−0.08, 0.12) | − 0.04 | (−0.14, 0.06) |
| MECPP | −0.12 | (−0.22, −0.03)c | −0.13 | (−0.23, −0.04)d | −0.03 | (−0.11, 0.09) | −0.04 | (−0.14, 0.06) | 0.03 | (−0.07, 0.13) | − 0.02 | (−0.12, 0.08) |
| ∑DEHP | −0.14 | (−0.24, −0.05)d | −0.14 | (−0.24, −0.05)d | −0.06 | (−0.16, 0.04) | −0.06 | (−0.16, 0.04) | 0.02 | (−0.08, 0.12) | − 0.03 | (−0.13, 0.07) |
FSH, follicle-stimulating hormone; LH, luteinizing hormone; T, testosterone; E2, oestradiol; SHBG, sex hormone-binding globulin; FAI, free androgen index; FT, free testosterone; MEHP, mono(2-ethylhexyl) phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; R, correlation coefficient; CI, confidence interval.
a
N = 424 for inhibin B.
b
N = 405 for E2 and E2/T ratio.
c
p-value ≤ 0.05.
d
p-value ≤ 0.01.