Table 5.
Multivariate analysis for men’s reproductive hormones and di(2-ethylhexyl) phthalate (DEHP) metabolite concentrations (n = 363)a
| FSH |
LH |
T |
Inhibin Bb |
E2c |
SHBG |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
| MEHP | 0.01 | (−0.03, 0.06) | 0.01 | (−0.03, 0.05) | 0.007 | (−0.03, 0.04) | −0.01 | (−0.04, 0.03) | − 4.6 | (−10.4, 1.1) | 0.05 | (0.02, 0.09)e |
| MEHHP | 0.01 | (−0.04, 0.06) | −0.01 | (−0.05, 0.03) | −0.01 | (−0.04, 0.03) | −0.001 | (−0.04, 0.03) | − 2.6 | (−8.4, 3.2) | 0.03 | (−0.01, 0.07) |
| MEOHP | 0.01 | (−0.04, 0.05) | −0.01 | (−0.05, 0.03) | −0.01 | (−0.04, 0.03) | −0.001 | (−0.04, 0.04) | − 2.9 | (−8.8, 3.0) | 0.03 | (−0.01, 0.07) |
| MECPP | 0.001 | (−0.05, 0.05) | −0.02 | (−0.06, 0.03) | −0.01 | (−0.04, 0.03) | −0.001 | (−0.04, 0.04) | − 1.8 | (−8.1, 4.4) | 0.02 | (−0.02, 0.06) |
| ∑DEHP | 0.01 | (−0.04, 0.06) | −0.01 | (−0.05, 0.03) | −0.01 | (−0.04, 0.03) | −0.001 | (−0.04, 0.04) | − 2.5 | (−8.7, 3.7) | 0.03 | (−0.01, 0.07) |
| FAI |
FT |
FAI/LH ratio |
FT/LH ratio |
E2/T ratioc |
T/LH ratio |
|||||||
| β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | β | 95% CI | |
| MEHP | −0.05 | (−0.08, −0.02)e | −0.02 | (−0.05, 0.01) | −0.06 | (−0.10, −0.01)d | −0.03 | (−0.07, 0.02) | −0.03 | (−0.07, 0.02) | −0.001 | (−0.05, 0.04) |
| MEHHP | −0.04 | (−0.07, −0.004)d | −0.02 | (−0.05, 0.01) | −0.03 | (−0.08, 0.02) | −0.02 | (−0.06, 0.03) | −0.004 | (−0.05, 0.04) | 0.001 | (−0.05, 0.05) |
| MEOHP | −0.04 | (−0.07, −0.01)d | −0.02 | (−0.05, 0.01) | −0.03 | (−0.08, 0.03) | −0.01 | (−0.06, 0.04) | −0.003 | (−0.05, 0.04) | 0.005 | (−0.04, 0.05) |
| MECPP | −0.03 | (−0.06, 0.004) | −0.02 | (−0.05, 0.01) | −0.01 | (−0.07, 0.04) | −0.003 | (−0.05, 0.05) | 0.003 | (−0.04, 0.05) | 0.009 | (−0.04, 0.06) |
| ∑DEHP | −0.04 | (−0.07, −0.003)d | −0.02 | (−0.05, 0.01) | −0.03 | (−0.08, 0.03) | −0.01 | (−0.06, 0.04) | −0.002 | (−0.05, 0.04) | 0.004 | (−0.05, 0.05) |
FSH, follicle-stimulating hormone; LH, luteinizing hormone; T, testosterone; E2, oestradiol; SHBG, sex hormone-binding globulin; FAI, free androgen index; FT, free testosterone; MEHP, mono(2-ethylhexyl) phthalate; MEHHP, mono(2-ethyl-5-hydroxyhexyl) phthalate; MEOHP, mono(2-ethyl-5-oxohexyl) phthalate; MECPP, mono(2-ethyl-5-carboxypentyl) phthalate; β, regression coefficient; CI, confidence interval.
Controlling for age, age square, body mass index (BMI), smoking status (current smoker vs. never smoked), ethnicity (African-American vs. others), urinary creatinine concentration, time of sample collection and time of collection squared.
N = 362 for inhibin B.
N = 346 for E2 and E2/T ratio.
p-value ≤ 0.05.
p-value ≤ 0.01.