Fig. 1.

Discordance and similarity between humans with FA and FA mouse models. FA-associated phenotypes in humans and mice are illustrated in a Venn-like diagram. FA phenotypes (lower diagram) are depicted in the common area between the two circles when shared between humans and mice or further away from the common area when phenotypes only partially overlap. We propose that, due to environmental and genetic differences between humans and laboratory mice (upper diagram), humans rely on an effective FA pathway to ensure normal development and tumour suppression, whereas mice are less dependent on an active FA pathway.