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. 2012 Jul 5;6(1):72–83. doi: 10.1242/dmm.008946

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 3. — Ultrastructural analysis of Sp^Δ/Δ cortical neurons reveals a massive disorganization of the microtubule network within axonal swellings. (A–H) Ultrathin sections of DIV6 primary cultures of cortical neurons from Sp^Δ/Δ (A–F) and Sp^+/+ mouse embryos (G–H). Images B and D are higher magnifications of axonal swellings indicated by arrows in images A and C, respectively. Images E, F and H are higher magnification of boxed regions in images B, D and G, respectively. Note the obvious disorganization and the tangled and bent aspect of microtubules within axonal swellings of Sp^Δ/Δ cortical neurons (B,D–F). This abnormal appearance of microtubules was never observed in Sp^+/+ axons, in which microtubules are always organized in parallel arrays (G–H). White arrows indicate microtubules (E,F,H). Scale bars: 5 μm (A,C); 0.5 μm (B,D,G); 0.25 μm (E,F,H).