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. 2012 Aug 16;6(1):95–105. doi: 10.1242/dmm.010116

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 5. — Mannose supplementation rescues mpi morphants. (A) Phenotype rescue of mpi morphants treated with 50 mM mannose at 4 dpf. Liver visualized using Tg(fabp10:dsRed). Scale bar: 100 μm. (B) 77% of mpi morphants treated with 50 mM mannose from fertilization through 4 dpf appear completely normal, whereas no rescue is seen with glucose. *P<0.0001 by Fisher’s exact test as compared with mpi MO + water or mpi MO + glucose supplementation. (C) Liver size is improved in mpi morphants treated with mannose supplementation. *P<0.0001 by Fisher’s exact test. (D) Mpi activity is not significantly changed with mannose supplementation. (E) FACE analysis with quantification showing restoration of G₃M₉ LLO levels in mpi morphants treated with mannose as compared with mpi MO alone. Average of two experiments. (F) LLO and M6P levels are increased in mpi morphants treated with mannose to 105% and 68%, respectively. Average of two experiments. Numbers in parentheses under n values indicate the number of experiments.