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. 2012 Jul 19;6(1):125–134. doi: 10.1242/dmm.009167

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 2. — Upon challenge with oxazolone, human leukocytes (mainly consisting of T cells) infiltrate the dermis and epidermis. (A,B) Photomicrographs of immunohistochemically stained paraffin sections of the skin: (A) stained with anti-hCD45 antibody and (B) stained with anti-CD3 antibody. Skin samples for both A and B were taken from the following mice: BALB/c mouse challenged with ethanol (a); non-engrafted NOD-scid IL2Rγ^null mouse (b); BALB/c mouse challenged with oxazolone (c); and engrafted NOD-scid IL2Rγ^null mouse treated with oxazolone (d). Arrows indicate invaded human leukocytes. Scale bars: 100 μm; 10 μm (insets).