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. 2012 Jul 19;6(1):125–134. doi: 10.1242/dmm.009167

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 4. — Treatment-dependent human IgG and IgE secretion. (A,B) PBMC derived from three different patients suffering from AD and from two healthy volunteers (non-AD) were analyzed in vitro and in vivo with respect to their capacity to secrete human IgG (A) and IgE (B). Sample sizes: in vitro AD n=3; in vitro non-AD n=2; in vivo AD after treatment with IL-4 n=5, NaCl n=4, ethanol n=13 or oxazolone n=12; in vivo non-AD after treatment with IL-4 n=8, NaCl n=4, ethanol n=8 or oxazolone n=9. (A) hIgG secretion. IL-4 had moderate effects on IgG levels in vitro and in vivo, whereas ethanol and oxazolone induced the secretion of hIgG. (B) hIgE secretion. IL-4 induced IgE secretion in vitro in the AD group and in one donor of the non-AD group, whereas in vivo IL-4 failed to induce hIgE in both groups. Ethanol and oxazolone induced hIgE secretion in the AD group but not the non-AD group. IgE levels in the four different groups were significantly different. Kruskal-Wallis test followed by multiple comparisons revealed that the oxazolone- and ethanol-treated groups were significantly different to the IL-4-treated group (P=0.01 and P=0.01, respectively).