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. 2012 Jul 19;6(1):125–134. doi: 10.1242/dmm.009167

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 5. — Immunological background of the donor determines the CD4:CD8 ratio in organs of engrafted NOD-scid IL2R γ ^null mice. (A,B) CD4:CD8 ratio of human T cells in the spleen, blood and skin of mice engrafted with PBMC derived from a patient suffering from AD and two healthy volunteers (non-AD) was compared with the CD4:CD8 ratio in whole blood from the respective donors prior to engraftment. (A) Representative flow cytometric analysis of human T cells stained with anti-human CD4 and CD8. (B) Quantitative analysis of CD4:CD8 ratio. Sample sizes: AD n=4, non-AD1 n=4 and non-AD2 n=7.