Fig. 2.

Core body temperature and activity in 8- to 10-month-old 3xTgAD mice. (A–I) Core body temperature (°C) and activity (counts/minute) were monitored continuously by remote radiotelemetry over a 7-day period at 8 (temperature, A; activity, F), 9 (temperature, B; activity, G) and 10 (temperature, C; activity, H) months of age in the same groups of individually housed 3xTgAD and Non-Tg mice. The mean 24-hour profiles over the 7 days (expressed as change,Δ) are illustrated in A–C for temperature and F–H for activity. Grey lines show Non-Tg mice and black lines 3xTgAD mice. White bars on the abscissa represent the light, inactive phase of the day whereas black bars represent the dark, active phase. The peak-trough amplitude in temperature rhythms was increased in 8, 9 and 10-month-old 3xTgAD mice (D). A phase advance in temperature rhythms was observed in 3xTgAD mice at all ages (E). An increase in peak-trough amplitude for activity rhythms in 3xTgAD mice was observed at 10 months of age (I) in the absence of any difference in the phase onset for activity rhythms (J). Data are expressed as mean ± s.d. and individual values for each animal are represented. Open circles, Non-Tg mice; black closed circles, 3xTgAD mice; n=9–15 per group. **P<0.01, ***P<0.001 versus age-matched Non-Tg control mice using two-way repeated measures ANOVA.