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. 2012 Nov 26;154(1):25–35. doi: 10.1210/en.2012-1728

Fig. 6.

Fig. 6.

Demethylating agent 5′-aza-CdR inhibits growth of tumors induced by FTC-236 cells in mouse xenograft models. A, Growth curves of FTC-236-induced tumors. FTC-236 cancer cells were sc inoculated into the right flank of athymic NCr-nu/nu mice. Mice were treated by weekly ip injection of 5′-aza-CdR (5 mg/kg; n = 6) or vehicle control (n = 6) for 30 d. Data are presented as mean ± se. *, P < 0.01; **, P < 0.001. B, Comparison of the weight of FTC-236 cell-induced tumors after treatment of 5′-aza-CdR (n = 6) or vehicle control (n = 6) at study endpoint. The data are represented as mean ± se. The differences are significant (P < 0.001).