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Effect of AT1R or AT2R blockers on the effect of A-II, A-III, A-IV, and Ang1-7 on aldosterone or cortisol production. Confluent cells were serum deprived in DMEM:F12 containing 0.1% Cosmic Calf serum for 24 h. Pretreatments with or without Losartan (10 μm) or PD123319 (1 μm) for 30 min were performed for each experiment before adding A-II (10 nm) or A-III (10 nm). *, P < 0.01 vs. A-II stimulation without antagonist, n = 4; †, P < 0.01 vs. A-III stimulation without antagonist, n = 4.
