Table 1.

Baseline parameters in 12- and 15-wk-old (WT) and db/db mice

Parameter	Main effects	P value	WT (10)	db/db (9)	WT (10)	db/db (9)
Age			12.1 ± 0.1	12.1 ± 0.1	15.2 ± 0.1	15.2 ± 0.1
Body mass (g)	Strain	0.001
	Age	0.079
	Interaction	0.228	25.7 ± 0.5a	48.8 ± 1.2	26.1 ± 0.6b	51.0 ± 0.4
Heart weight (HW) (mg)	Strain	0.434
	Age	0.773
	Interaction	0.415	133 ± 5	133 ± 3	130 ± 5	139 ± 5
Tibia length (TL) (mm)	Strain	0.103
	Age	0.001
	Interaction	0.146	17.7 ± 0.2	16.8 ± 0.2c	18.3 ± 0.3	18.3 ± 0.3
HW/TL (mg/mm−1)	Strain	0.149
	Age	0.236
	Interaction	0.848	7.54 ± 0.24	7.91 ± 0.18	7.14 ± 0.32	7.62 ± 0.24
Fasting glucose (mmol/liter)	Strain	0.001
	Age	0.724
	Interaction	0.024	12.6 ± 0.7a	30.9 ± 1.0	17.2 ± 0.7b	26.7 ± 3.4
Fasting insulin (μU/ml)	Strain	0.001
	Age	0.491
	Interaction	0.373	5.5 ± 0.9a	55.9 ± 6.7	2.3 ± 0.1b	79.9 ± 28.9
HOMA-IR	Strain	0.001
	Age	0.752
	Interaction	0.702	2.9 ± 0.6a	78.5 ± 12.0	1.8 ± 0.1b	65.9 ± 29.3

Data represent mean ± se. Numbers in parentheses are sample sizes.

^aP < 0.05, strain within 12 wk.

^bP < 0.05, strain within 15 wk.

^cP < 0.05, age within db/db.