. 2012 Nov 16;154(1):246–252. doi: 10.1210/en.2012-1552

Table 1.

PAPP-A protein levels in aortic smooth muscle cell-conditioned medium

PAPP-A mutants	PAPP-A (mIU/ml)
WT	1.8 ± 0.10
E483A	4.3 ± 0.60^a
D1499A	1.7 ± 0.13
K1296A/K1316A	11.8 ± 1.92^a

E483A, Proteolytically inactive PAPP-A; D1499A, PAPP-A with proteolytic activity against IGFBP-5 but not IGFBP-4; K1296A/K1316A, non-cell-binding PAPP-A.

P < 0.05 vs. WT.