Fig. 1.

ChREBP ASO reduces hepatic and adipose tissue but not muscle ChREBP levels. A and B, ChREBP ASO decreased the expression in liver and eWAT but not muscle (A), and the decreased expression in liver corresponded with decreases in ChREBP protein (B) in pair-fed rats with matched body weights (C); C and D, ChREBP ASO reduced body weight (C) and 24-h food intake (D) in rats fed a fructose diet ad libitum; F and G, rats fed safflower oil had no changes in body weight (E), or in rats that were pair-fed fructose diet (F), and ChREBP ASO did not affect either plasma glucose (G) or insulin (H) concentrations. *, P < 0.05; **, P < 0.005.