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. 2012 Nov 16;154(1):36–44. doi: 10.1210/en.2012-1725

Fig. 2.

Fig. 2.

ChREBP ASO decreases lipogenic gene expression and protein but only reduces plasma triglycerides. A, Key lipogenic genes FAS and MTP were decreased with ChREBP ASO as assessed by quantitative RT-PCR; B, hepatic FAS protein levels were decreased with ChREBP ASO; C, the contribution of DNL as assessed with heavy water; D, the reductions in lipogenic genes resulted in significant reductions in plasma triglycerides on either safflower oil or fructose diet; E, however, there were no significant differences in triglyceride concentrations in liver, soleus, and gastrocnemius; F, additionally, hepatic diacylglycerols were unchanged on both safflower oil and fructose diets in ChREBP-ASO-treated-rats; G, lastly, ChREBP ASO reduced the plasma triglycerides during a tyloxapol challenge. #, P = 0.1; *, P < 0.05; **, P < 0.005.