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Simplified schematic representation of drug targets (yellow stars) in Wnt/β-catenin-mediated signaling. Four key aspects that regulate β-catenin-mediated signaling are highlighted: the destruction complex, the Wnt/β-catenin signalosome, cadherin junctions, and the hypoxia sensing system Hif-1α (hipoxia induced factor 1β). Proteins that directly interact with Wnt/β-catenin are marked as colored structures, other proteins are marked as circles.
