Table 1.

Small Molecules, which Downregulate Wnt/β-Catenin Signaling

Structure	Compound	Target	Reference
	XAV939	Tankyrases1, 2	[37]
	IWR1	Tankyrases1, 2	[38]
	IWP-1	Porcupine	[38]
	IWP-2	Porcupine	[38]
	JW74	Tankyrases1, 2	[39]
	JW55	Tankyrases1, 2	[40]
	Okadaic acid	PP2A phosphatase	[58]
	Tautomycin	PP1 phosphatase	[60]
	SB239063	p38 MAPK	[122, 137]
	SB203580	p38 MAPK	[122, 137]
	ADP-HPD	PARG	[148]
	2-[4-(4-fluorophenyl)piperazin-1-yl]-6-methylpyrimidin-4(3H)-one	Tankyrases1, 2	[165]
	PJ34	Tankyrases1, 2	[170]
	Niclosamide	Downregulates Dvl-2, triggers LRP6 degradation	[253, 254, 255]
	Cambinol	SIRT1	[278]
	Sulindac	PDZ domain of Dishevelled	[284, 479]
	3289-8625	Dishevelled	[286]
	Scaffold A for series of analogs	Dishevelled	[288]
	Scaffold B for series of analogs	Dishevelled	[288]
	J01-017a	Dishevelled	[288]
	NSC668036	Dishevelled	[289, 441]
	Filipin	Caveolin-mediated endocytosis	[291]
	IC261	CK1ε/δ	[308]
	PF670462	CK1δ and CK1ε	[308]
	Bosutinib	Src kinase	[356, 357]
	PHA665752	c-Met	[379, 386]
	Imatinib	Different tyrosine kinases	[385]
	ICG-001	CREB binding protein (CBP)	[434, 441]
	Ethacrynic acid	Lef-1	[437, 439]
	Ethacrynic acid derivative	Lef-1	[439]
	PKF115-584	β-catenin	[440, 441, 443]
	PNU-74654	β-catenin	[441, 443]
	PKF118-744	β-catenin	[440, 441, 443]
	CGP049090	β-catenin	[440, 441, 443]
	PKF118-310	β-catenin	[440, 441, 443]
	ZTM000990	β-catenin	[440, 441, 443]
	BC21	β-catenin	[444]
	GDC-0941	PI3K	[449]
	Rp-8-Br-cAMP	PKA	[461]