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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: J Pathol. 2012 Jun 6;228(2):170–180. doi: 10.1002/path.3992

Figure 3.

Figure 3

PAI-1 is associated with histopathological changes of pulmonary fibrosis following type II AEC injury. Diphtheria toxin (10.0 μg/kg) was administered for 14 days/protocol to three strains of mice: 1, DTR−: PAI-1+/+; 2, DTR+: PAI-1+/+; and 3, DTR+: PAI-1−/−. On day 21, lungs were harvested and 5 μm sections were generated for (A) Masson trichrome staining and (B) picrosirius red staining (DTR+: PAI-1+/+ and DTR+: PAI-1−/− groups only). Representative images are shown for two mice in each group, taken with a ×20 objective (Masson trichrome staining) and a ×40 objective (picrosirius red staining).