Table 1.

Advantage and disadvantage of methods for the diagnosis of macroprolactinemia.

	Advantage	Disadvantage
Polyethylene glycol (PEG)	Simple and inexpensive	Not highly specific
	Screening for macroprolactinemia
Gel chromatography	Accurate Confirming macroprolactinemia	Time consuming and expensive
Protein A/G	Identifying IgG-bound PRL (common cause of macroprolactin)	Expensive
125I-PRL binding	Identifying anti-PRL autoantibodies (common cause of IgG-bound PRL)	Time consuming and hazardous Needs radio isotope facilities