Table 6.
Prevalence of cardiac ion channel-related mutations in SIDS cohorts‡.
| Number of SIDS cases | |||
|---|---|---|---|
| Gene | Total | with mutation | Functionally significant |
| I Na related genes | |||
| SCN5A | 542 | 28 (5.2%) | 26 (4.8%) |
| SCN1B | 292 | 0 | 0 |
| SCN1Bb | 292 | 1 (0.3%) | 1 (0.3%) |
| SCN2B | 292 | 0 | 0 |
| SCN3B | 292 | 2 (0.7%) | 2 (0.7%) |
| SCN4B | 292 | 1 (0.3%) | 1 (0.3%) |
| CAV3 | 335 | 6 (1.8%) | 5 (1.5%) |
| GPD1-L | 221 | 2 (0.9%) | 2 (0.9%) |
| SNTA1 | 292 | 8 (2.7%) | 3 (1.0%) |
| I to related genes | |||
| KCND3 | 292 | 1 (0.3%) | 0 |
| I Ks related genes | |||
| KCNQ1 | 409 | 9 (2.2%) | 4 (1.0%) |
| KCNE1 | 367 | 1 (0.3%) | 0 |
| I Kr related genes | |||
| KCNH2 | 409 | 8 (2.0%) | 2 (0.5%) |
| KCNE2 | 367 | 2 (0.5%) | 1 (0.3%) |
| I K1 related genes | |||
| KCNJ2 | 201 | 0 | 0 |
| I K,ATP related genes | |||
| KCNJ8 | 292 | 2 (0.7%) | 2 (0.7%) |
| Intracellular calcium cycling related genes | |||
| RYR2 | 134 | 2 (1.5%) | 2 (1.5%) |
| Gap junctional current related genes | |||
| GJA1 | 292 | 2 (0.7%) | 1 (0.3%) |
I K,ATP: ATP-sensitive potassium current; I K1: inward rectifier potassium current; I Kr: rapid delayed rectifier potassium current; I Ks: slow delayed rectifier potassium current; I Na: fast sodium current; I to: transient outward potassium current.
‡Based on data listed in Table 5.