Table 2.

Atypical ductal hyperplasia (ADH) and ipsilateral breast tumor recurrence (IBTR).

Investigator	no. BCS specimens	no. lumpectomy + for ADH	IBTR ADH (+) no. (%)	IBTR in ADH (−) no. (%)	Median Followup (years)
Goldstein et al. [33]	94	54	3/54 (5.6)′	0/36 (0)′′	6.5
Fowble et al. [34]	460	99†	1/99 (1.0)	17/329 (5.2)	4.8
Greene et al. [35]	155*	87	0/87 (0%)**	1/68 (1.5)**	2.2

′ADH (+) at margin more recurrence than ADH (−) at margin P < 0.01.

′′Represents lesions negative for both ADH and COL.

^†ADH involved somewhere in specimen, not specifically involving margin.

*Lumpectomy performed for ADH, no malignancy in original specimen.

**denotes malignancy development and not recurrence as initial lumpectomy was negative for malignancy.