Table 2.
Odds Ratios for the Relations Between Biomarkers of Inflammation, Endothelial Function, and Adiposity and Overall Cancer Risk From Conditional Logistic Regression Analysesa, SU.VI.MAX Cohort, France, 1994–2007
| No. of Cases | No. of Controls | Unadjustedb Results |
Results From Multivariate Modelc |
Results From Multivariate Model Including All Studied Biomarkers |
||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |||
| hs-CRP | ||||||||
| Q1 | 111 | 272 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 124 | 261 | 1.17 | 0.86, 1.60 | 1.18 | 0.86, 1.62 | 1.20 | 0.87, 1.66 |
| Q3 | 119 | 265 | 1.13 | 0.82, 1.55 | 1.08 | 0.78, 1.49 | 1.10 | 0.78, 1.53 |
| Q4 | 158 | 226 | 1.81 | 1.32, 2.48 | 1.78 | 1.28, 2.47 | 1.78 | 1.26, 2.52 |
| P for trend | 0.0006 | 0.002 | 0.004 | |||||
| sICAM-1 | ||||||||
| Q1 | 113 | 269 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 129 | 258 | 1.21 | 0.89, 1.64 | 1.23 | 0.90, 1.67 | 1.32 | 0.96, 1.82 |
| Q3 | 118 | 265 | 1.05 | 0.77, 1.43 | 1.05 | 0.77, 1.45 | 1.09 | 0.78, 1.53 |
| Q4 | 152 | 232 | 1.56 | 1.16, 2.11 | 1.48 | 1.09, 2.02 | 1.51 | 1.06, 2.14 |
| P for trend | 0.012 | 0.035 | 0.068 | |||||
| sVCAM-1 | ||||||||
| Q1 | 139 | 244 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 121 | 265 | 0.81 | 0.60, 1.08 | 0.83 | 0.62, 1.13 | 0.80 | 0.59, 1.10 |
| Q3 | 116 | 266 | 0.76 | 0.56, 1.04 | 0.77 | 0.56, 1.05 | 0.70 | 0.50, 0.97 |
| Q4 | 136 | 249 | 0.95 | 0.71, 1.27 | 0.99 | 0.73, 1.34 | 0.85 | 0.61, 1.18 |
| P for trend | 0.7 | 0.9 | 0.3 | |||||
| Soluble E-selectin | ||||||||
| Q1 | 126 | 257 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 134 | 250 | 1.08 | 0.81, 1.45 | 1.09 | 0.81, 1.47 | 1.00 | 0.74, 1.36 |
| Q3 | 113 | 272 | 0.85 | 0.63, 1.16 | 0.84 | 0.62, 1.14 | 0.79 | 0.57, 1.09 |
| Q4 | 139 | 245 | 1.17 | 0.86, 1.58 | 1.14 | 0.83, 1.56 | 1.01 | 0.72, 1.42 |
| P for trend | 0.7 | 0.9 | 0.5 | |||||
| MCP-1 | ||||||||
| Q1 | 119 | 261 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 130 | 258 | 1.11 | 0.82, 1.50 | 1.07 | 0.79, 1.46 | 1.03 | 0.75, 1.41 |
| Q3 | 130 | 252 | 1.13 | 0.84, 1.53 | 1.09 | 0.80, 1.48 | 1.04 | 0.76, 1.42 |
| Q4 | 133 | 253 | 1.16 | 0.85, 1.58 | 1.08 | 0.79, 1.48 | 1.03 | 0.74, 1.43 |
| P for trend | 0.3 | 0.6 | 0.6 | |||||
| Leptin | ||||||||
| Q1 | 134 | 249 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 121 | 264 | 0.85 | 0.63, 1.16 | 0.82 | 0.60, 1.12 | 0.77 | 0.55, 1.06 |
| Q3 | 126 | 258 | 0.91 | 0.67, 1.23 | 0.87 | 0.63, 1.20 | 0.82 | 0.58, 1.14 |
| Q4 | 131 | 253 | 0.97 | 0.68, 1.38 | 0.84 | 0.56, 1.25 | 0.70 | 0.46, 1.07 |
| P for trend | 0.9 | 0.4 | 0.2 | |||||
| Adiponectin | ||||||||
| Q1 | 1 | Reference | 1 | Reference | 1 | Reference | ||
| Q2 | 135 | 248 | 0.83 | 0.61, 1.12 | 0.86 | 0.63, 1.17 | 0.87 | 0.63, 1.19 |
| Q3 | 119 | 265 | 0.98 | 0.72, 1.33 | 1.04 | 0.76, 1.41 | 1.11 | 0.80, 1.52 |
| Q4 | 134 | 251 | 0.88 | 0.65, 1.19 | 0.92 | 0.67, 1.26 | 0.92 | 0.66, 1.27 |
| P for trend | 124 | 260 | 0.6 | 0.9 | 1.0 | |||
Abbreviations: CI, confidence interval; hs-CRP, high-sensitivity C-reactive protein; MCP-1, monocyte chemoattractant protein-1; OR, odds ratio; Q, quartile; sICAM-1, soluble intercellular adhesion molecule 1; SU.VI.MAX, Supplémentation en Vitamines et Minéraux Antioxydants; sVCAM-1, soluble vascular cell adhesion molecule 1.
a Cutoffs for sex-specific quartiles were: hs-CRP—0.6, 1.1, 2.2 in men and 0.5, 0.9, 1.9 in women; sICAM-1—199.0, 243.8, 288.0 in men and 194.0, 232.0, 272.8 in women; sVCAM-1—532.6, 652.0, 786.0 in men and 538.0, 652.0, 800.0 in women; soluble E-selectin—41.5, 30.6, 51.4 in men and 23.6, 33.0, 42.9 in women; MCP-1—225.0, 267.0, 315.0 in men and 183.0, 222.0, 268.0 in women; leptin—2.4, 4.1, 6.6 in men and 5.9, 10.0, 17.0 in women; adiponectin—4.3, 6.4, 9.2 in men and 8.9, 12.0, 16.3 in women. All statistical tests were 2-sided.
b Cases and controls were matched by sex, age, body mass index, and SU.VI.MAX intervention group.
c Adjusted for sex, age, body mass index, height, SU.VI.MAX intervention group, alcohol intake, physical activity, smoking status, and educational level.