Table 3.
Odds Ratios for the Relations Between Biomarkers of Inflammation, Endothelial Function, and Adiposity and Breast Cancer Risk From Conditional Logistic Regression Analysesa, SU.VI.MAX Cohort, France, 1994–2007
| No. of Cases | No. of Controls | Unadjustedb Results |
Results From Multivariate Modelc |
Results From Multivariate Model Including All Studied Biomarkers |
||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |||
| hs-CRP | ||||||||
| Q1 | 52 | 112 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 55 | 109 | 1.09 | 0.68, 1.75 | 1.16 | 0.71, 1.88 | 1.30 | 0.77, 2.19 |
| Q3 | 53 | 111 | 1.05 | 0.66, 1.67 | 0.93 | 0.57, 1.51 | 1.06 | 0.63, 1.79 |
| Q4 | 58 | 104 | 1.24 | 0.75, 2.05 | 1.25 | 0.73, 2.14 | 1.40 | 0.79, 2.49 |
| P for trend | 0.5 | 0.7 | 0.4 | |||||
| sICAM-1 | ||||||||
| Q1 | 48 | 123 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 57 | 104 | 1.44 | 0.90, 2.32 | 1.47 | 0.90, 2.41 | 1.75 | 1.03, 2.98 |
| Q3 | 49 | 116 | 1.07 | 0.67, 1.72 | 1.15 | 0.70, 1.89 | 1.43 | 0.83, 2.47 |
| Q4 | 64 | 93 | 1.77 | 1.12, 2.81 | 1.57 | 0.97, 2.54 | 1.86 | 1.06, 3.26 |
| P for trend | 0.05 | 0.1 | 0.048 | |||||
| sVCAM-1 | ||||||||
| Q1 | 61 | 92 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 51 | 114 | 0.69 | 0.44, 1.08 | 0.72 | 0.46, 1.15 | 0.72 | 0.44, 1.17 |
| Q3 | 50 | 123 | 0.61 | 0.38, 0.98 | 0.64 | 0.39, 1.04 | 0.56 | 0.33, 0.95 |
| Q4 | 56 | 107 | 0.79 | 0.50, 1.25 | 0.84 | 0.51, 1.36 | 0.72 | 0.42, 1.24 |
| P for trend | 0.3 | 0.4 | 0.1 | |||||
| Soluble E-selectin | ||||||||
| Q1 | 56 | 114 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 63 | 104 | 1.19 | 0.77, 1.84 | 1.25 | 0.80, 1.95 | 1.11 | 0.69, 1.79 |
| Q3 | 45 | 116 | 0.80 | 0.50, 1.28 | 0.79 | 0.48, 1.28 | 0.72 | 0.42, 1.23 |
| Q4 | 54 | 102 | 1.08 | 0.67, 1.74 | 1.02 | 0.61, 1.70 | 0.90 | 0.51, 1.60 |
| P for trend | 0.8 | 0.5 | 0.3 | |||||
| MCP-1 | ||||||||
| Q1 | 52 | 114 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 54 | 110 | 1.08 | 0.68, 1.72 | 1.10 | 0.68, 1.79 | 1.04 | 0.63, 1.73 |
| Q3 | 53 | 100 | 1.16 | 0.73, 1.85 | 1.25 | 0.77, 2.01 | 1.22 | 0.74, 2.00 |
| Q4 | 59 | 112 | 1.17 | 0.73, 1.86 | 1.14 | 0.70, 1.85 | 1.09 | 0.66, 1.81 |
| P for trend | 0.5 | 0.5 | 0.5 | |||||
| Leptin | ||||||||
| Q1 | 55 | 103 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 64 | 102 | 1.16 | 0.73, 1.83 | 1.09 | 0.67, 1.76 | 0.99 | 0.59, 1.65 |
| Q3 | 51 | 116 | 0.80 | 0.51, 1.26 | 0.81 | 0.50, 1.33 | 0.75 | 0.44, 1.29 |
| Q4 | 48 | 115 | 0.69 | 0.39, 1.20 | 0.64 | 0.34, 1.20 | 0.51 | 0.26, 1.02 |
| P for trend | 0.09 | 0.1 | 0.08 | |||||
| Adiponectin | ||||||||
| Q1 | 58 | 110 | 1 | Reference | 1 | Reference | 1 | Reference |
| Q2 | 48 | 119 | 0.77 | 0.49, 1.23 | 0.80 | 0.50, 1.30 | 0.83 | 0.50, 1.38 |
| Q3 | 55 | 102 | 1.04 | 0.64, 1.68 | 1.12 | 0.68, 1.85 | 1.29 | 0.76, 2.21 |
| Q4 | 57 | 105 | 1.04 | 0.65, 1.67 | 1.13 | 0.68, 1.87 | 1.15 | 0.67, 1.97 |
| P for trend | 0.6 | 0.4 | 0.3 | |||||
Abbreviations: CI, confidence interval; hs-CRP, high-sensitivity C-reactive protein; MCP-1, monocyte chemoattractant protein-1; OR, odds ratio; Q, quartile; sICAM-1, soluble intercellular adhesion molecule 1; SU.VI.MAX, Supplémentation en Vitamines et Minéraux Antioxydants; sVCAM-1, soluble vascular cell adhesion molecule 1.
a Cutoffs for female-specific quartiles were: hs-CRP—0.5, 0.9, 1.9; sICAM-1—194.0, 232.0, 272.8; sVCAM-1—538.0, 652.0, 800.0; soluble E-selectin—23.6, 33.0, 42.9; MCP-1—183.0, 222.0, 268.0; leptin—5.9, 10.0, 17.0; adiponectin—8.9, 12.0, 16.3. All statistical tests were 2-sided.
b Cases and controls were matched by sex, age, body mass index, and SU.VI.MAX intervention group.
c Adjusted for age, body mass index, height, SU.VI.MAX intervention group, alcohol intake, physical activity, smoking status, and educational level.