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Cotton rats were infected with 100 infectious Litomosoides sigmodontis L3 larvae and intranasally challenged with 5×104 M. tuberculosis (MTB) bacteria 11 weeks later, a timepoint by which they had developed a patent (microfilaria (Mf)-releasing) filaria infection. At 20 weeks cotton rats were euthanized and immunological and histological studies performed. Numbers in brackets indicate the number of analyzed cotton rats in the first and second experiment.
