Fig. 4.

Association between prescribed TT and mortality by region. Interaction between TT and region (P < 0.0001). Longer TT was associated with lower mortality in Eur/ANZ [HR = 0.94 (95% CI: 0.91–0.97) per 30 min TT, P = 0.0002] and Japan [HR = 0.75 (95% CI: 0.69–0.81), P < 0.0001] but not in North America [HR = 0.98 (95% CI: 0.95–1.02), P = 0.28]. Model was adjusted for age, sex, race, time on dialysis, BMI, 13 summary comorbid conditions, residual kidney function, prescribed blood flow rate and catheter use, stratified by study phase and accounted for facility clustering. The chosen reference category was for North American patients with prescribed TT at 240 min.