Table 2.
Associations between prescribed TT categories and risk of mortality/hospitalizationa
| Categorical TT (standard regression model) |
||||
|---|---|---|---|---|
| 180 min | 210 min | 240 min | 270–300 min | |
| All-cause mortality | ||||
| Unadjustedb | 1.30 (1.22–1.40) | 1.18 (1.11–1.26) | 1.00 (reference) | 0.78 (0.71–0.85) |
| Adjustedc | 1.16 (1.07–1.24) | 1.06 (0.99–1.13) | 1.00 (reference) | 0.90 (0.83–0.98) |
| Cardiovascular death | ||||
| Unadjustedb | 1.29 (1.17–1.42) | 1.18 (1.07–1.29) | 1.00 (reference) | 0.87 (0.77–0.98) |
| Adjustedc | 1.18 (1.06–1.31) | 1.06 (0.96–1.17) | 1.00 (reference) | 0.97 (0.86–1.10) |
| Sudden death | ||||
| Unadjustedb | 1.30 (1.13–1.49) | 1.10 (0.96–1.26) | 1.00 (reference) | 0.76 (0.63–0.91) |
| Adjustedc | 1.19 (1.02–1.38) | 0.99 (0.86–1.14) | 1.00 (reference) | 0.84 (0.70–1.01) |
| Any hospitalization | ||||
| Unadjustedb | 1.14 (1.08–1.20) | 1.01 (0.96–1.06) | 1.00 (reference) | 0.93 (0.89–0.98) |
| Adjustedc | 1.10 (1.04–1.16) | 1.00 (0.94–1.05) | 1.00 (reference) | 0.99 (0.94–1.05) |
| Cardiovascular hospitalization | ||||
| Unadjustedb | 1.08 (1.01–1.16) | 1.05 (0.98–1.13) | 1.00 (reference) | 0.99 (0.92–1.07) |
| Adjustedc | 1.07 (1.00–1.15) | 1.04 (0.97–1.11) | 1.00 (reference) | 1.01 (0.93–1.10) |
| Hospitalization due to CHF or fluid overload | ||||
| Unadjustedb | 1.26 (1.11–1.43) | 1.12 (0.99–1.27) | 1.00 (reference) | 0.92 (0.79–1.08) |
| Adjustedc | 1.24 (1.09–1.42) | 1.10 (0.97–1.24) | 1.00 (reference) | 0.94 (0.80–1.11) |
aHRs (95% CI) shown for each outcome. CHF, congestive heart failure.
bModel stratified by country and study phase and accounted for facility clustering.
cModel stratified by country and study phase, adjusted for age, sex, race, time on dialysis, BMI, 13 summary comorbid conditions, residual kidney function, prescribed blood flow rate and catheter use and accounted for facility clustering.