Table II.
Chemopreventive efficacy of isothiocyanates (ITCs) in transgenic mouse models
| Agent | Transgenic mouse model | Experimental protocol | Effect | Reference |
|---|---|---|---|---|
| PEITC | ApcMin/+ mouse model of gastrointestinal cancer | Dietary administration of 0.05% PEITC | Inhibition of intestinal polyp development and reduced intestinal tumor size | (47) |
| Polyoma middle-T antigen (PyMT) transgenic mouse model of breast cancer | Dietary feeding of 8 mmol PEITC/kg | Reduced size of mammary cancer lesions | (48) | |
| Transgenic adenocarcinoma of mouse prostate (TRAMP) model of prostate cancer | Dietary feeding of 0.05% PEITC alone or 0.025% PEITC + 1% curcumin | Inhibition of prostate tumor incidence | (49) | |
| Transgenic adenocarcinoma of mouse prostate (TRAMP) model of prostate cancer | Dietary administration of 3 mmol PEITC/kg | Inhibition of incidence and burden of poorly-differentiated prostate tumor | (50) | |
| BITC | MMTV-neu transgenic mouse model of breast cancer | Dietary administration of 3 mmol BITC/kg | Suppression of incidence and/or burden of hyperplasia and carcinoma | (51) |
| SFN | ApcMin mouse model of gastrointestinal cancer | Dietary feeding of ~6 μmol SFN/day | Suppression of polyp formation | (52) |
| ApcMin/+ mouse model of gastrointestinal cancer | Dietary feeding of 300 or 600 ppm of SFN | Suppression of polyps in the small intestine | (53) | |
| Transgenic adenocarcinoma of mouse prostate (TRAMP) model of prostate cancer | Oral gavage of 6 μmol SFN thrice a week | Inhibition of prostate intraepithelial neoplasia and pulmonary metastasis | (54) | |
| Transgenic adenocarcinoma of mouse prostate (TRAMP) model of prostate cancer | Feeding with 240mg broccoli sprouts/mouse/day | Inhibition of prostate tumor growth | (55) |
Abbreviations: PEITC, Phenethyl isothiocyanate; BITC, Benzyl isothiocyanate; SFN, Sulforaphane