Table 3.
Select Metabolizing Enzymes and Transporters, Highly Active Combination Antiretroviral Therapy, and Chemotherapy [80, 81]
| Enzyme | HAART Inhibitor | HAART Inducer | Chemotherapy |
|---|---|---|---|
| CYP3A4 | Delavirdine, ritonavir, amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, saquinavir | Nevirapine, efavirenz | Paclitaxel, docetaxel, erlotinib, sunitinib, sorafenib, etoposide, vincristine, vinblastine, vinorelbine, cyclophosphamide |
| CYP2C9 | Efavirenz, ritonavir | Cyclophosphamide | |
| CYP2C19 | Efavirenz, amprenavir | Cyclophosphamide, ifosfamide, thalidomide | |
| CYP2D6 | Ritonavir | Tamoxifen | |
| CYP2B6 | Efavirenz, nelfanivir, ritonavir | Nevirapine | Cyclophosphamide, ifosfamide |
| CYP2E1 | Ritonavir | Etoposide, dacarbazine | |
| UGT1A1 | Atazanavir | Irinotecan |
Abbreviation: HAART, highly active combination antiretroviral therapy.