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Flow diagram of included/excluded studies.
Abbreviations: ACR, American College of Rheumatology; bDMARD, biological disease-modifying anti-rheumatic drug; DMARD, disease-modifying anti-rheumatic drug; ETN, etanercept; HAQ, Health Assessment Questionnaire; MTX, Methotrexate; RCT, randomized controlled trial; TEMPO, Trial of Etanercept and Methotrexate with radiographic Patient Outcomes; TNF-α, tumour necrosis factor alpha.
